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IRBP-002B
IRBP, Interphotoreceptor Retinoid Binding Protein Fragment
Ser-Gly-Ile-Pro-Tyr-Ile-Ile-Ser-Tyr-Leu-His-Pro-Gly-Asn-Thr-Ile-Leu-His-Val-Asp
Size:5mg
P1(RMB):1880
MW:2209.5
One letter sequence:SGIPYIISYLHPGNTILHVD
Molecular Formula:
Description:This 20-residue peptide, a major pathogenic T-cell epitope (161–180), is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP). It has been shown to induce posterior uveitis (EAU).
Literature Reference:Sonoda, K. et al. J. Immunol. 171, 2652 (2003); Read, RW. and SR. Barnum, ARVO Meeting Abstracts 43, 2281 (2002); Silver, P. et al. Invest. Ophthal. Vis. Sci. 36, 946 (1995); Karabekian, Z. et al. Invest. Ophthalmol. Vis. Sci. 46, 3769 (2005).
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