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AMYD-015B
human pyroglutamate (3-40) amyloid
Glp-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Val-Gly-Asp-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
Size:1mg
P1(RMB):1490
MW:4125.7
One letter sequence:Glp-FRHDSGYEVHHQKLVFFAEVGDSNKGAIIGLMVGGVV
Molecular Formula:
Description:The fibrils in the plaques formed in the brains of patients with Alzheimer’s disease contain significant amounts of truncated Aß proteins. This fragments contain an N-terminal pyroglutamic acid. The g-carboxy group of glutamic acid forms a cyclic bond with the free N-terminal amino group to form pyroglutamate
Literature Reference:Ref: Mok, SS. et al. J. Neurosci. Res. 61, 449 (2000); Russo, C. et al. Nature. 405, 531 (2000)
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