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LHRH-015A
Buserelin(NHNH2)
Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHNH2 Trifluoroacetate salt
Size:5mg
P1(RMB):335
MW:1239.44
One letter sequence:Pyr-HWSYs(tBu)-LRP-NHNH2
Molecular Formula:C58H83N17O13
Description:Buserelin is a longer acting synthetic peptide analog of the naturally occurring gonadotropin-releasing hormone (GnRH/LHRH). Substitution of glycine in position 6 by D-serine and that of glycinamide in position 10 by ethylamide, leads to a nonapeptide with a significantly enhanced LHRH effect. The effects of buserelin on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) release are approximately 20 to 170 times higher than those of natural LHRH.
Literature Reference:F.Roila, Biomed. Pharmacother., 43, 279 (1989) R.N.Brogden et al., Drugs, 39, 399 (1990) A.Imai et al., Am. J. Obstet. Gynecol., 182, 1142 (2000) Y.Wang et al., Eur. J. Endocrinol., 146, 447 (2002) A.Imai et al., Int. J. Oncol., 20, 987 (2002) J.Franklin et al., J. Endocrinol., 176, 275 (2003) Merck Index, 14th ed., No. 1503, (2006)
Cas:57982-77-1
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