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LHRH-022B
Cetrorelix
Ac-D-2-Nal-4-chloro-D-Phe-β-(3-pyridyl)-D-Ala-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2 Acetate salt
Size:5mg
P1(RMB):2020
MW:1431.06
One letter sequence:Ac-D-2-Nal-4-chloro-D-F-β-(3-pyridyl)-D-ASY-D-Cit-LRPa-NH2
Molecular Formula:C70H92ClN17O14
Description:GnRH antagonist. CAS Number (cetrorelix acetate): 145672-81-7. This peptide is offered and sold solely for uses reasonably related to the development and submission of information under a Federal law which regulates the manufacture, use or sale of drugs (the “Bolar Exemption”). Bachem cannot be made liable for any infringement of intellectual property rights. It is the sole and only responsibility of the purchaser or user of this product to comply with the relevant national rules and regulations. A highly modified luteinizing hormone-releasing hormone (LHRH) decapeptide with a terminal amide group, this peptide is a LHRH antagonist. It regulates the expression of Galphas and Galphai protein subunits and adenylate cyclase activity in ovary, breast and pituitary. Cetrorelix competitively inhibits LHRH receptor in the pituitary gland to suppress ovarian and testicular functions.
Literature Reference:T.Reissmann et al., Hum. Reprod. Update, 6, 322 (2000) G.Emons et al., Endocr. Relat. Cancer, 10, 291 (2003) D.B.Shapiro and D.Mitchell-Leef, Minerva Ginecol., 55, 373 (2003) C.Gründker et al., Eur. J. Endocrinol., 151, 141 (2004)
Cas:120287-85-6
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