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ENFU-001B
Enfuvirtide
Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
Size:5mg
P1(RMB):2190
MW:4491.94
One letter sequence:Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2
Molecular Formula:C204H301N51O64
Description:HIV binds to the host CD4+ cell receptor via the viral protein gp120; gp41. Enfuvirtide binds to gp41 preventing the conformational changes in gp41 which is necessary for fusion of the virus with the cell.
Literature Reference:H.B.Fung and Y.Guo, Clin. Ther., 26, 352 (2004) R.Manfredi and S.Sabbatani, Curr. Med. Chem., 13, 2369 (2006) J.Ruof et al., Clin. Drug Investig., 27, 469 (2007) A.Streinu-Cercel et al., HIV Clin. Trials, 9, 375 (2008)
Cas:159519-65-0
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