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TAT-002B
HIV-1 TAT Protein Peptide
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg
Size:1.0mg
P1(RMB):429
MW:1559.9
One letter sequence:YGRKKRRQRRR
Molecular Formula:C64H118N32O14
Description:This is the most characterized fragment of the HIV transactivator protein (TAT). This arginine-rich TAT peptide penetrates plasma membrane directly, but not through endocytosis, and has been proven to promote the entry of nucleic acids into several cell types.
Literature Reference:C. Rudolph, et al., JBC Papers in Press, M211891200, (2003) V.P. Torchilin, et al., PNAS, 100, 1972-1977, (2003) Wang, H. et al. J. Clin. Invest. 109, 1463 (2002) Ziegler et al. Biochem. 44, 138 (2005) Wender, PA. et al. Proc. Natl. Acad. Sci. USA 97, 13003 (2000).
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