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PKCP-018A
Melittin
Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
Size:0.5mg
P1(RMB):582
MW:2846.5
One letter sequence:GIGAVLKVLTTGLPALISWIKRKRQQ-NH2
Molecular Formula:C131H229N39O31
Description:26-residue polypeptide isolated from bee venom that binds calmodulin in a Ca2+ dependent manner, activates phospholipase A2, and inhibits protein kinase C (IC50 = 5-7 m M) by binding to the catalytic domain in a Mg-ATP sensitive manner. IC50 of 1-4 μM.
Literature Reference:Raynor et al., J. Biol. Chem., 266, 2753 (1991); Schweitz, Toxicon, 22, 308 (1984)
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