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PKCP-007A
Calcineurin Autoinhibitory Peptide
Ile-Thr-Ser-Phe-Glu-Glu-Ala-Lys-Gly-Leu-Asp-Arg-Ile-Asn-Glu-Arg-Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro
Size:1.0mg
P1(RMB):766
MW:2930.4
One letter sequence:ITSFEEAKGLDRINERMPPRRDAMP
Molecular Formula:C124H205N39O39S2
Description:Amino acid sequence of this peptide that is identical with the C-terminal region of the calmodulin-bing domain. It inhibits Mn2+-stimulated calcineurin activity (IC50 = 10 m M) using [32P] myosin light chain as a substrate but has no effect on Ni2+ -stimulated activity.
Literature Reference:Y. Hashimoto et al., J. Biol. Chem., 265, 1924 (1990)
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