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AMYD-050B
(Arg6)-Amyloid β-Protein (1-40)
Asp-Ala-Glu-Phe-Arg-Arg-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val Trifluoroacetate salt
Size:1mg
P1(RMB):1700
MW:4348.91
One letter sequence:DAEFRRDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Molecular Formula:C194H300N54O58S
Description:This peptide is the English (H6R) mutation of β-amyloid, which accelerates fibrillation without increasing protofibril formation. The English and Tottori mutations alter Aβ assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers. The exchange of His6 by Arg influences the structure of the Cu2+ complex formed by Aβ peptides.
Literature Reference:Y.Hori et al., J. Biol. Chem., 282, 4916 (2007) K.Ono et al., J. Biol. Chem., 285, 23186 (2010) B.Alies et al., Inorg. Chem., 50, 11192 (2011)
Cas:N/A
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