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AMYD-048A
Amyloid β/A4 Protein Precursor770 (135-155)
Phe-Leu-His-Gln-Glu-Arg-Met-Asp-Val-Cys-Glu-Thr-His-Leu-His-Trp-His-Thr-Val-Ala-Lys
Size:0.5mg
P1(RMB):321
MW:2618
One letter sequence:FLHQERMDVCETHLHWHTVAK
Molecular Formula:C116H173N35O31S2
Description:This peptide comprises a Cu2+-binding site. Binding of Cu2+ to the peptide induced oxidation of the cysteine and intermolecular dimerization of the peptide. The reduction of Cu2+ to Cu+ by Amyloid β/A4 Protein Precursor may enhance the production of hydroxyl radicals which in turn may contribute to neurodegeneration in Alzheimer's disease.
Literature Reference:G.Multhaup et al., Science, 271, 1406 (1996)
Cas:315229-44-8
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