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GVIA-001B
ω-Conotoxin GVIA
Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2(Cys1 and Cys16/Cys8 and Cys19/ Cys15 and Cys26 Bridge)
Size:1mg
P1(RMB):1380
MW:3037.39
One letter sequence:CKS-Hyp-GSSCS-Hyp-TSYNCCRSCN-Hyp-YTKRCY-NH2(Cys1 and Cys16/Cys8 and Cys19/ Cys15 and Cys26 Bridge)
Molecular Formula:C120H182N38O43S6
Description:ω-Conotoxin GVIA from the venom of the fish-hunting cone snail Conus geographus efficiently blocks N-type calcium channels. This presynaptic inhibition of calcium influx prevents the voltage-activated release of acetylcholine.
Literature Reference:B.M.Olivera et al., Biochemistry, 23, 5087 (1984) B.M.Olivera et al., Biochemistry, 26, 2086 (1987) J.Rivier et al., J. Biol. Chem., 262, 1194 (1987) D.R.Hillyard et al., Neuron, 9, 69 (1992) K.Sato et al., Biochem. Biophys. Res. Commun., 194, 1292 (1993) J.R.Abbott and M.J.Litzinger, Int. J. Devl Neurosci., 12, 43 (1994)
Cas:106375-28-4
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